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1

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Singer, Mervyn, Deutschman, Clifford S., Seymour, Christopher Warren, Shankar-Hari, Manu, Annane, Djillali, Bauer, Michael, Bellomo, Rinaldo, Bernard, Gordon R., Chiche, Jean-Daniel, Coopersmith, Crai

Journal:

JAMA The Journal of the American Medical Association

Year:

2016

Language:

english

File:

PDF, 398 KB

english, 2016

2

Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration in COVID-19 (REALIST-COVID-19): A structured summary of a study protocol for a randomised, controlled trial

Gorman, Ellen, Shankar-Hari, Manu, Hopkins, Phil, Tunnicliffe, William S., Perkins, Gavin D., Silversides, Jonathan, McGuigan, Peter, Jackson, Colette, Boyle, Roisin, McFerran, Jamie, McDowell, Cliona

Journal:

Year:

2020

File:

PDF, 440 KB

2020

3

Do we need a new definition of sepsis?

Shankar-Hari, Manu, Deutschman, Clifford S., Singer, Mervyn

Journal:

Intensive Care Medicine

Year:

2015

Language:

english

File:

PDF, 164 KB

english, 2015

4

Developing a New Definition and Assessing New Clinical Criteria for Septic Shock

Shankar-Hari, Manu, Phillips, Gary S., Levy, Mitchell L., Seymour, Christopher W., Liu, Vincent X., Deutschman, Clifford S., Angus, Derek C., Rubenfeld, Gordon D., Singer, Mervyn

Journal:

JAMA The Journal of the American Medical Association

Year:

2016

Language:

english

File:

PDF, 672 KB

english, 2016

5

Assessment of Clinical Criteria for Sepsis

Seymour, Christopher W., Liu, Vincent X., Iwashyna, Theodore J., Brunkhorst, Frank M., Rea, Thomas D., Scherag, André, Rubenfeld, Gordon, Kahn, Jeremy M., Shankar-Hari, Manu, Singer, Mervyn, Deutschma

Journal:

JAMA The Journal of the American Medical Association

Year:

2016

Language:

english

File:

PDF, 651 KB

english, 2016

6

Judging quality of current septic shock definitions and criteria

Shankar-Hari, Manu, Bertolini, Guido, Brunkhorst, Frank M., Bellomo, Rinaldo, Annane, Djillali, Deutschman, Clifford S., Singer, Mervyn

Journal:

Critical Care (BioMed Central)

Year:

2015

Language:

english

File:

PDF, 704 KB

english, 2015

7

Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study

Conway Morris, Andrew, Datta, Deepankar, Shankar-Hari, Manu, Stephen, Jacqueline, Weir, Christopher J., Rennie, Jillian, Antonelli, Jean, Bateman, Anthony, Warner, Noel, Judge, Kevin, Keenan, Jim, Wan

Journal:

Intensive Care Medicine

Year:

2018

Language:

english

File:

PDF, 984 KB

english, 2018

8

Using Bayesian Methods to Augment the Interpretation of Critical Care Trials: An Overview of Theory and Example Reanalysis of the Alveolar Recruitment Trial

Zampieri, Fernando G, Casey, Jonathan D, Shankar-Hari, Manu, Harrell Jr., Frank E., Harhay, Michael O

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2020

File:

PDF, 734 KB

2020

9

Continuous renal replacement therapy (CRRT) in patients with liver disease: Is circuit life different?

Banwari Agarwal, Steve Shaw, Manu Shankar Hari, Andrew K. Burroughs, Andrew Davenport

Journal:

Journal of Hepatology

Year:

2009

Language:

english

File:

PDF, 111 KB

english, 2009

10

A life-threatening sore throat masquerading as swine flu

Vanessa Kahr, Nicholas A Barrett, Manu Shankar-Hari, Hannah Slack, Rebecca L Preston, Caoimhe Nic Fhogartaigh, Jonathan Edgeworth, Richard Beale

Journal:

Year:

2010

Language:

english

File:

PDF, 174 KB

english, 2010

11

Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective

Manu Shankar-Hari, Jo Spencer, William A Sewell, Kathryn M Rowan, Mervyn Singer

Journal:

Critical Care (BioMed Central)

Year:

2012

Language:

english

File:

PDF, 821 KB

english, 2012

12

Statin therapy in critical illness: an international survey of intensive care physicians’ opinions, attitudes and practice

Manu Shankar-Hari, Peter S Kruger, Stefania Di Gangi, Damon C Scales, Gavin D Perkins, Danny F McAuley, Marius Terblanche

Journal:

BMC Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 228 KB

english, 2012

13

Neurogenic diabetes insipidus presenting in a patient with subacute liver failure: a case report

Manu Shankar Hari, Anthony K Parsons, Andy K Burroughs…

Journal:

Journal of Medical Case Reports

Year:

2010

Language:

english

File:

PDF, 1.33 MB

english, 2010

14

How might a diagnostic microRNA signature be used to speed up the diagnosis of sepsis?

Shankar-Hari, Manu, Lord, Graham M

Journal:

Expert Review of Molecular Diagnostics

Year:

2014

Language:

english

File:

PDF, 293 KB

english, 2014

15

Activated protein C in severe acute pancreatitis without sepsis? Not just yet...

Manu Shankar-Hari,Duncan Wyncoll

Journal:

Critical Care (BioMed Central)

Year:

2010

Language:

english

File:

PDF, 118 KB

english, 2010

16

The influence of statin exposure on inflammatory markers in patients with early bacterial infection: pilot prospective cohort study

Shankar-Hari, Manu, Donnelly, Antonia, Pinto, Ruxandra, Salih, Zaid, McKenzie, Cathrine, Terblanche, Marius, Adhikari, Neill KJ

Journal:

BMC Anesthesiology

Year:

2014

Language:

english

File:

PDF, 317 KB

english, 2014

17

Healthcare-associated bloodstream infections in critically ill patients: descriptive cross-sectional database study evaluating concordance with clinical site isolates

Culshaw, Nick, Glover, Guy, Whiteley, Craig, Rowland, Katie, Wyncoll, Duncan, Jones, Andrew, Shankar-Hari, Manu

Journal:

Annals of Intensive Care

Year:

2014

Language:

english

File:

PDF, 281 KB

english, 2014

18

The diagnostic and prognostic significance of monitoring blood levels of immature neutrophils in patients with systemic inflammation

Mare, Tracey, Treacher, David, Shankar-Hari, Manu, Beale, Richard, Lewis, Sion, Chambers, David, Brown, Kenneth

Journal:

Critical Care (BioMed Central)

Year:

2015

Language:

english

File:

PDF, 1.36 MB

english, 2015

19

Intravenous immunoglobulin for severe sepsis and septic shock: clinical effectiveness, cost-effectiveness and value of a further randomised controlled trial

Soares, Marta O, Welton, Nicky J, Harrison, David A, Peura, Piia, Shankar-Hari, Manu, Harvey, Sheila E, Madan, Jason, Ades, Anthony E, Rowan, Kathryn M, Palmer, Stephen J

Journal:

Critical Care (BioMed Central)

Year:

2014

Language:

english

File:

PDF, 549 KB

english, 2014

20

Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis

Shankar-Hari, Manu, Culshaw, Nicholas, Post, Benjamin, Tamayo, Eduardo, Andaluz-Ojeda, David, Bermejo-Martín, Jesús F., Dietz, Sebastian, Werdan, Karl, Beale, Richard, Spencer, Jo, Singer, Mervyn

Journal:

Intensive Care Medicine

Year:

2015

Language:

english

File:

PDF, 1.84 MB

english, 2015

21

Evidence for a causal link between sepsis and long-term mortality: a systematic review of epidemiologic studies

Shankar-Hari, Manu, Ambler, Michael, Mahalingasivam, Viyaasan, Jones, Andrew, Rowan, Kathryn, Rubenfeld, Gordon D.

Journal:

Critical Care (BioMed Central)

Year:

2016

Language:

english

File:

PDF, 797 KB

english, 2016

22

The critically ill patient: making the referral to intensive care

Elnour, Shaima, Shankar-Hari, Manu

Journal:

British Journal of Hospital Medicine

Year:

2011

Language:

english

File:

PDF, 186 KB

english, 2011

23

Defining Septic Shock—Reply

Shankar-Hari, Manu, Singer, Mervyn

Journal:

JAMA The Journal of the American Medical Association

Year:

2016

Language:

english

File:

PDF, 76 KB

english, 2016

24

Understanding Long-Term Outcomes Following Sepsis: Implications and Challenges

Shankar-Hari, Manu, Rubenfeld, Gordon D.

Journal:

Current Infectious Disease Reports

Year:

2016

Language:

english

File:

PDF, 1.19 MB

english, 2016

25

The critically ill patient: identification and initial stabilization

Elnour, Shaima, Shankar-Hari, Manu

Journal:

British Journal of Hospital Medicine

Year:

2011

Language:

english

File:

PDF, 186 KB

english, 2011

26

Activation-Associated Accelerated Apoptosis of Memory B Cells in Critically Ill Patients With Sepsis

Shankar-Hari, Manu, Fear, David, Lavender, Paul, Mare, Tracey, Beale, Richard, Swanson, Chad, Singer, Mervyn, Spencer, Jo

Journal:

Critical Care Medicine

Year:

2017

Language:

english

File:

PDF, 563 KB

english, 2017

27

The intensive care medicine research agenda on septic shock

Perner, Anders, Gordon, Anthony C., Angus, Derek C., Lamontagne, Francois, Machado, Flavia, Russell, James A., Timsit, Jean-Francois, Marshall, John C., Myburgh, John, Shankar-Hari, Manu, Singer, Merv

Journal:

Intensive Care Medicine

Year:

2017

Language:

english

File:

PDF, 1.10 MB

english, 2017

28

Predictive value of cell-surface markers in infections in critically ill patients: protocol for an observational study (ImmuNe FailurE in Critical Therapy (INFECT) Study)

Conway Morris, Andrew, Datta, Deepankar, Shankar-Hari, Manu, Weir, Christopher J, Rennie, Jillian, Antonelli, Jean, Rossi, Adriano G, Warner, Noel, Keenan, Jim, Wang, Alice, Brown, K Alun, Lewis, Sion

Journal:

Year:

2016

Language:

english

File:

PDF, 540 KB

english, 2016

29

Differences in Impact of Definitional Elements on Mortality Precludes International Comparisons of Sepsis Epidemiology—A Cohort Study Illustrating the Need for Standardized Reporting*

Shankar-Hari, Manu, Harrison, David A., Rowan, Kathryn M.

Journal:

Critical Care Medicine

Year:

2016

Language:

english

File:

PDF, 618 KB

english, 2016

30

Divide and conquer: identifying acute respiratory distress syndrome subphenotypes

Shankar-Hari, Manu, McAuley, Daniel F

Journal:

Year:

2017

Language:

english

File:

PDF, 473 KB

english, 2017

31

Can Concurrent Abnormalities in Free Light Chains and Immunoglobulin Concentrations Identify a Target Population for Immunoglobulin Trials in Sepsis?

Shankar-Hari, Manu, Singer, Mervyn, Spencer, Jo

Journal:

Critical Care Medicine

Year:

2017

Language:

english

File:

PDF, 637 KB

english, 2017

32

Septic shock resuscitation in the first hour

Simpson, Nicholas, Lamontagne, Francois, Shankar-Hari, Manu

Journal:

Current Opinion in Critical Care

Year:

2017

Language:

english

File:

PDF, 220 KB

english, 2017

33

Just Because Things Are Not Different, Does Not Mean They Are the Same

Shankar-Hari, Manu, Rubenfeld, Gordon D.

Journal:

Critical Care Medicine

Year:

2017

Language:

english

File:

PDF, 71 KB

english, 2017

34

Protocolised early goal-directed therapy in patients with sepsis/septic shock does not result in improved survival compared with usual care with less invasive resuscitation strategies

Meyer, Joel, Shankar-Hari, Manu

Journal:

Evidence-Based Medicine

Year:

2017

Language:

english

File:

PDF, 381 KB

english, 2017

35

Caring for Sepsis Patients: An Update

Shankar-Hari, Manu, Singer, Mervyn

Journal:

Critical Care Clinics

Year:

2017

Language:

english

File:

PDF, 146 KB

english, 2017

36

Immune Activation in Sepsis

Conway-Morris, Andrew, Wilson, Julie, Shankar-Hari, Manu

Journal:

Critical Care Clinics

Year:

2017

Language:

english

File:

PDF, 313 KB

english, 2017

37

Sepsis

Shankar-Hari, Manu, Singer, Mervyn

Journal:

Critical Care Clinics

Year:

2018

File:

PDF, 21 KB

2018

38

Immunoglobulins and sepsis

Shankar-Hari, Manu, Madsen, Martin Bruun, Turgeon, Alexis F.

Journal:

Intensive Care Medicine

Year:

2018

Language:

english

File:

PDF, 677 KB

english, 2018

39

Estimating attributable fraction of mortality from sepsis to inform clinical trials

Shankar-Hari, Manu, Harrison, David A., Rowan, Kathryn M., Rubenfeld, Gordon D.

Journal:

Journal of Critical Care

Year:

2018

Language:

english

File:

PDF, 3.15 MB

english, 2018

40

Lymphocyte subset expression and serum concentrations of PD-1/PD-L1 in sepsis - pilot study

Wilson, Julie K., Zhao, Yuan, Singer, Mervyn, Spencer, Jo, Shankar-Hari, Manu

Journal:

Critical Care (BioMed Central)

Year:

2018

Language:

english

File:

PDF, 599 KB

english, 2018

41

Race, Ethnicity, and Sepsis

Shankar-Hari, Manu, Rubenfeld, Gordon D.

Journal:

Critical Care Medicine

Year:

2018

Language:

english

File:

PDF, 55 KB

english, 2018

42

qSOFA, Cue Confusion

Singer, Mervyn, Shankar-Hari, Manu

Journal:

Annals of Internal Medicine

Year:

2018

Language:

english

File:

PDF, 60 KB

english, 2018

43

Relationship between Anaemia, Haemolysis, Inflammation and Haem Oxygenase-1 at Admission with Sepsis: a pilot study

Ekregbesi, Phebe, Shankar-Hari, Manu, Bottomley, Christian, Riley, Eleanor M., Mooney, Jason P.

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 1.44 MB

english, 2018

44

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial

Calfee, Carolyn S, Delucchi, Kevin L, Sinha, Pratik, Matthay, Michael A, Hackett, Jonathan, Shankar-Hari, Manu, McDowell, Cliona, Laffey, John G, O'Kane, Cecilia M, McAuley, Daniel F, Johnston, Andrew

Journal:

The Lancet Respiratory Medicine

Year:

2018

Language:

english

File:

PDF, 320 KB

english, 2018

45

Early PREdiction of sepsis using leukocyte surface biomarkers: the ExPRES-sepsis cohort study

Shankar-Hari, Manu, Datta, Deepankar, Wilson, Julie, Assi, Valentina, Stephen, Jacqueline, Weir, Christopher J., Rennie, Jillian, Antonelli, Jean, Bateman, Anthony, Felton, Jennifer M., Warner, Noel,

Journal:

Intensive Care Medicine

Year:

2018

Language:

english

File:

PDF, 1.31 MB

english, 2018

46

Major surgery and the immune system

Shankar Hari, Manu, Summers, Charlotte

Journal:

Current Opinion in Critical Care

Year:

2018

Language:

english

File:

PDF, 356 KB

english, 2018

47

Lessons From ARDS for Non-ARDS Research

Rubenfeld, Gordon D., Shankar-Hari, Manu

Journal:

Year:

2018

Language:

english

File:

PDF, 113 KB

english, 2018

48

Do Sepsis-3 Criteria Facilitate Earlier Recognition of Sepsis and Septic Shock? A Retrospective Cohort Study

Scheer, Christian S., Kuhn, Sven-Olaf, Fuchs, Christian, Vollmer, Marcus, Modler, Arnd, Brunkhorst, Frank, Shankar-Hari, Manu, Hahnenkamp, Klaus, Gründling, Matthias, Rehberg, Sebastian

Journal:

Year:

2019

Language:

english

File:

PDF, 995 KB

english, 2019

49

Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials

Santhakumaran, Shalini, Gordon, Anthony, Prevost, A. Toby, O’Kane, Cecilia, McAuley, Daniel F., Shankar-Hari, Manu

Journal:

Year:

2019

Language:

english

File:

PDF, 1.31 MB

english, 2019

50

Risk Factors at Index Hospitalization Associated With Longer-term Mortality in Adult Sepsis Survivors

Shankar-Hari, Manu, Harrison, David A., Ferrando-Vivas, Paloma, Rubenfeld, Gordon D., Rowan, Kathryn

Journal:

JAMA Network Open

Year:

2019

Language:

english

File:

PDF, 1.27 MB

english, 2019